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PIEZO2 Ion Channel Presents New Target for Pain Research

New NCCIH-supported research suggests the PIEZO2 mechanoreceptor is essential for light touch detection after injury in mice and humans, and that PIEZO2 antagonists may provide a new avenue for relieving a variety of chronic pain conditions.

Study identifies gene that makes gentle touch feel painful after injury

NIH-funded research raises possibility of designer treatments for common form of pain.

New research suggests the PIEZO2 gene may play an essential role in the nervous system’s reaction to injury and inflammation, making it a target for developing precise treatments for relieving pain caused by cuts, burns, and other skin injuries.

PIEZO2 Ion Channel Presents New Target for Pain Research

New NCCIH-supported research suggests the PIEZO2 mechanoreceptor is essential for light touch detection after injury in mice and humans, and that PIEZO2 antagonists may provide a new avenue for relieving a variety of chronic pain conditions.

New Study Links Mindfulness, Brain Changes, and Pain Sensitivity

People who are naturally more mindful report less pain and show lower activation of a specific region of the brain in response to an unpleasant heat stimulus, according to a new study supported by the National Center for Complementary and Integrative Health (NCCIH). The study, conducted by researchers from Wake Forest University and collaborating institutions, was published in the journal Pain.

Yoga for Pain

This issue of NCCIH Clinical Digest offers information on yoga and certain pain conditions.

New Grants To Study Behavioral Interventions for Opioid Addiction and Recovery

Overdose deaths, opioid misuse, addiction to prescription opioids or to illicit drugs such as heroin, and chronic pain management are tough problems that are often related to each other. Together, they form a daunting public health crisis that is of great concern and significance to many in the United States, including the National Center for Complementary and Integrative Health (NCCIH) and much of the National Institutes of Health (NIH). 

Defining the Prevalence of Chronic Pain in the United States

This Research Spotlight highlights new data suggesting that in 2016 nearly 20 percent of U.S. adults had chronic pain and 8 percent had high-impact chronic pain (pain that limited at least one major life activity).

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